Pharmacokinetic Software for Research and Education

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Screen Shots and Features Tour of PK Solutions

  Curve Area

• The Curve Areas sheet is automatically set up and completed each time the New Data Set button is clicked. No user inputs are required on this sheet. The Curve Areas sheet can be used independently from other program features to provide AUC calculations from any data set.
• The sheet displays all basic calculations for the area under the curve (AUC) and the first moment of the area (AUMC). Areas are calculated using the trapezoid rule. The literature shows that other area measurement methods, such as the log-trapezoid, spline, and others do not statistically improve the accuracy of the area measurements given the variance inherent in the data and the limited number of observations. Therefore, PK Solutions uses the simple trapezoid procedure.
• The area results for each each segment of the curve (partials) are tabulated and graphed. This novel display is primarily useful in bioequivalence studies.
• Many PK parameters can be determined using either AUC data or exponential terms. In these cases, PK Solutions shows both results.